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-synuclein, which happens to be a main part of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) pressure, suggest that dysfunction in the intracellular proteinase devices, such as ubiquitin-proteasome system or lysosomal program, which eliminates unne